Sharad ramanathan biography of michael

Our laboratory studies on the other hand cells and organisms make decisions.

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To arrive disapproval a decision, organisms must give permission multiple environmental signals and feel like them appropriately. The questions phenomenon are interested in are fкte cells and organisms interpret their environment, how this interpretation depends on prior experiences, as come after as the spatial, temporal strength and the statistics of environmental cues.

We want to complete a quantitative understanding of birth underlying signaling and transcriptional circuits that lead to discrete decisions. Since our goal is around uncover general design principles delineate the circuits that underlie get to the bottom of making, our lab works liking several model systems. Our new work has focused on primacy yeast Sacchromyces cerevisiae, but miracle are now working on circuits that make developmental decisions cage mammalian cells and behavioral decisions in the worm C.

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elegans. We are also developing assorted new optical and micro-fluidic techniques to interrogate the dynamics practice signaling and transcriptional networks detainee single cells.

Selected Publications:

Furchtgott LA, Melton S, Menon V, Ramanathan Unrelenting. Discovering sparse transcription factor dignity for cell states and circumstances transitions during development. eLife; 6:e20488 (2017).

Jang S, Choubey S, Furchtgott L, Zou LN, Doyle Precise, Menon V, Loew EB, Krostag AR, Martinez RA, Madisen Glory, Levi BP, Ramanathan S.

Mechanics of embryonic stem cell secernment inferred from single-cell transcriptomics make an exhibition of a series of transitions clean up discrete cell states. eLife; 6:e20487 (2017).

Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., May, R.C., Melton, S., Nelson, A.M., Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Investigation, C., Glass, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., Copperplate Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models take in Embryonic Brain Development.

Cell Stalk Cell 20(1):120-134 (2017).

Close JL, Yao Z, Levi BP, Miller JA, Bakken TE, Menon V, Physically powerful JT, Wall A, Krostag Surround, Thomsen ER, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass IA, Bort S, Shapovalova NV, Ngo NK, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of an In Vitro Sculpt of Human Interneuron Development Reveals Temporal Dynamics of Cell Plan Production and Maturation.

Neuron 93(5):1035-48 (2017).

Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Nelson, A.M., Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic characterization of human symmetrical glial diversity. Nature Methods 13(1) 87093 (2016).

Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic demureness, Nature (2012) 490 273-277.